ABSTRACT
In recent years, domestic and foreign studies have found that vitamin D deficiency is widespread in adults and children.Neonates and pregnant women are at high risk of vitamin D deficiency.Vitamin D deficiency during pregnancy is associated with adverse pregnancy outcomes, such as premature birth, limited fetal growth and also has an adverse impact on the development of neonatal nervous system and respiratory disease susceptibility.This paper reviews the effects of vitamin D deficiency on neonates during pregnancy.
ABSTRACT
In recent years, domestic and foreign studies have found that vitamin D deficiency is wide-spread in adults and children. Neonates and pregnant women are at high risk of vitamin D deficiency. Vitamin D deficiency during pregnancy is associated with adverse pregnancy outcomes, such as premature birth, limited fetal growth and also has an adverse impact on the development of neonatal nervous system and respiratory dis-ease susceptibility. This paper reviews the effects of vitamin D deficiency on neonates during pregnancy.
ABSTRACT
High volume hemofiltration(HVHF) is an important development in the field of blood purification,which has a significant effect on the stability of hemodynamics,clearance of inflammatory factors and metabolic toxins in the body. HVHF also has some drawbacks in the treatment. At present,HVHF has an increasingly wide application in pediatric critical diseases,such as systemic inflammatory response syndrome, sepsis or septic shock,multiple organ dysfunction syndrome,acute kidney injury,acute poisoning,etc. It has become an important treatment in pediatric emergency medicine.
ABSTRACT
Objective To study the characteristics of liver injury induced by simvastatin combined with HRZ (Isoniazid,Rifampicin and Pyrazinamide) in SD rats.Methods Fifty-four 8-week-old SD rats were randomly divided into 3 groups:group A (control),group B (HRZ) and group C (simvastatin combined to HRZ),half of each group were male.We calculated the accurate dose respectively before those rats were given intragastrical administration of corresponding drugs.Six rats were killed in each group on 10th,20th and 40th day,respectively.Before this,blood was fastened from femoral of every rat that would be killed to test liver function,liver tissue slices were made in order to observe the pathological characteristic.Results Alanine amiotransferase of group C elevated in line with time and reached statistic difference on 40th day,furthermore,it was significantly higher than group A (P＜0.05).Total bilirubin and direct Bilirubin of group C were significantly higher than those of group A from the beginning to the end (P＜0.05),however,they declined rapidly on 10th day,this trend also had statistic difference (P＜0.05) At the end of this experiment,hepatic cords was disordered slightly,but swelling liver cells and vacuolar degeneration were observed,the nuleus of cell condensed.Soakage of monocytes,neutrophils,and lymphocytes occurred in the portal and lobule regions,or even spotty necrosis occasionally.Conclusion Cholestasis occurs at the early stage when simvastatin is combined with HRZ in SD rats,however,it has a rapidly degressive trend.In contrast,Alanine amiotransferase elevates,furthermore,pathological injury or even spotty necrosis can emerge in liver tissue slices.